CDMO Service

Amino Acid Modification

Precision chemical modification of amino acids including fluorescent labeling, isotope incorporation, PEGylation, and protection chemistry.

Service Overview

SynthAxis provides expert amino acid modification services for researchers who require custom-functionalized building blocks for peptide synthesis, metabolic labeling, structural studies, and diagnostic applications.

Our modification capabilities span fluorescent dye conjugation, stable isotope labeling (13C, 15N, 2H), PEGylation, protection group chemistry, click chemistry handle introduction, and protonation/deprotonation salt conversion.

Each modified amino acid is comprehensively characterized by NMR, HPLC, and mass spectrometry. We offer both catalog-scale quantities and custom large-scale production with full analytical documentation.

Key Capabilities

Fluorescent dye labeling (FITC, TAMRA, Cy3/5, BODIPY)
Stable isotope incorporation: 13C, 15N, 2H
PEGylation for improved solubility and half-life
N-terminal and side-chain protection/deprotection
Click chemistry handle introduction (azide, alkyne, tetrazine)
Protonation and deprotonation (salt form conversion)
Fmoc and Boc protection for SPPS applications
Unnatural amino acid synthesis and incorporation
Full NMR, HPLC, and MS characterization
Chiral purity determination by chiral HPLC
Custom modification protocol development
mg to multi-gram scale production