Amino Acid Chiral Resolution
Advanced chiral resolution services to separate racemic amino acid mixtures with high enantiomeric excess using multiple resolution strategies.
Service Overview
SynthAxis provides comprehensive chiral resolution services for amino acids and their derivatives. Our team applies the most appropriate resolution method based on scale, substrate, and target enantiomeric excess requirements.
We offer six resolution approaches: membrane resolution, capillary electrophoresis, chemical resolution with chiral resolving agents, preparative chiral chromatography, preferential crystallization, and enzymatic kinetic resolution. Each method is optimized to achieve ee values typically exceeding 99%.
Resolved enantiomers are fully characterized by specific optical rotation, chiral HPLC analysis, and NMR spectroscopy. We provide complete documentation suitable for pharmaceutical regulatory submissions.
Key Capabilities
Related Sub-Services
Chromatographic Resolution
Preparative chiral HPLC using polysaccharide and Pirkle-type stationary phases for milligram to kilogram separation.
Enzymatic Resolution
Kinetic resolution using acylases, lipases, and aminotransferases with high enantioselectivity.
Crystallization Resolution
Diastereomeric salt formation and preferential crystallization for bulk-scale amino acid resolution.
Chemical Resolution
Resolution via diastereomeric derivatives using chiral resolving agents such as tartaric acid or DBTA.