CDMO Service

PNA Dimers Synthesis

Sequence-defined PNA dimer synthesis for antisense applications, diagnostics, and advanced nucleic acid hybridization research.

Service Overview

SynthAxis provides custom PNA dimer synthesis services for researchers working in antisense gene regulation, diagnostic probe development, and nucleic acid nanotechnology. PNA dimers offer enhanced binding affinity compared to monomers while serving as efficient building blocks for longer oligomers.

We synthesize PNA dimers using both solution-phase and solid-supported approaches, selecting the most appropriate method based on sequence composition and scale requirements. Protecting group strategies are tailored to each dimer to minimize side reactions.

All PNA dimers are verified by HPLC purity analysis and ESI or MALDI mass spectrometry. Larger quantities for oligomer assembly are available with competitive pricing and short lead times.

Key Capabilities

Solution-phase PNA dimer synthesis
Solid-supported PNA dimer preparation
Boc and Fmoc compatible dimer building blocks
All standard homobase and heterobase combinations
Modified base-containing dimers on request
Fluorescent and biotin-labeled dimers available
HPLC purity ≥95% standard
ESI-MS and MALDI-MS confirmation
Designed for use in automated SPPS assemblers
Gram-scale production capability
Bulk pricing for oligomer manufacturing workflows
Rapid delivery for standard combinations