PNA Monomers Synthesis
Custom synthesis of PNA monomers with backbone modifications, base variations, and conjugated handles for nucleic acid research and antisense therapy.
Service Overview
SynthAxis offers custom PNA (peptide nucleic acid) monomer synthesis for researchers who require building blocks beyond our standard catalog. Our synthetic chemists are experienced in both Boc and Fmoc PNA chemistry, providing monomers of consistently high purity.
Custom monomers include backbone-modified variants (γ-PNA, miniPEG-PNA, cyclopentyl-constrained PNA), base-modified monomers (pseudocomplementary bases, universal bases, C5-modified pyrimidines), and functionalized monomers with biotin, fluorescent dyes, or click chemistry handles.
All custom PNA monomers are characterized by 1H/13C NMR, HPLC, and high-resolution mass spectrometry. Optical purity is confirmed by chiral HPLC where applicable.